HOUSE: It'll end horribly.

THIRTEEN: Not for him. She may take all his money, and he may be a naive idiot but he'll always be hopeful, so he'll always be happy.

HOUSE: You lost your mother. You euthanized your brother. You got the life expectancy of a pretty good sitcom. If you can convince yourself that you'd be miserable no matter what, even without all that stuff, the maybe you don't have to hate the universe, for dumping a giant turd on you. Fatalism is your survival mechanism.